Effect of Aqeuos and Methanol Exctracts of S[pondias mombin fruit on CCL4 – induced hepatotoxicity in Albino Rats.

Abstract

The effect of aqueous and methanol extracts of Spondias mombin fruit on Carbon tetrachloride (CCl4) induced liver damage in albino rats were determined. Six groups consisting of five (5) albino rats each were used for this study. Dosages of 250 and 500mg/kg bodyweight of Aqueous and Methanol extracts of S. mombin were administered to test groups alongside with control group. Biochemical parameters such as liver and antioxidants enzymes concentration were monitored following standard procedures. The level of serum ALT, AST and ALP significantly (p<0.05) increased in the group that was induced with CCl4 (85.95±0.94, 64.06±1.76 and 96.26±1.78U/l) respectively when compared with the normal group. However, the administration of aqueous extract of S. mombin at 500mg/kg body weight significantly (p<0.05) decreased the level of ALT, AST and ALP (46.84±1.56, 9.99±0.90 and 34.43±2.42U/l) in the serum respectively. The administration of Aqueous and methanol extracts of S. mombin at 250 and 500mg/kg body weight significantly (p<0.05) decreased the level of ALT, AST and ALP in the serum. The activities of liver SOD and Catalase in the extracts treated groups were significantly increased when compared with control mostly in a dose - dependent manner. An increase was observed in the level of MDA in the CCl4 treated group compared to the normal rats group and this was decreased more significantly on administration with aqueous extract at 500mg/kg. Thus, S. mombin fruit extract may serve as promising candidate for the management of hepatic damage