SUBCHRONIC TOXICOLOGICAL STUDIES OF CALYX OF Annona senegalens1s USED AS A ·SLURRY SAUCE

Abstract

Many plants and plant parts are eaten as food and provide humans with higher nutritional requirements than animals. Calyx of the flowers of Annona senegalensis is used as slurry sauce by the Nupe speaking people of Niger State, Nigeria. Sub-chronic toxicify studies of the methanol extract of the calyx was carried out for twenty eight days by oral administration once daily at of 250, 500 and 1000 mg/ kg bodyweight to rats in groups one, two, and three respectively while the fourth group (control) received 0.Sml of normal saline. At the end of the experiment, rats were anaesthetized under chloroform vapor and blood samples were collected by carotid puncture for some hematological and biochemical oarameters using Agape and randox kits.