Antiulcerogenic activities of Agelanthus dodoneifolius leaf against acetyl salicylate and ethanol induced ulceration in rats

Abstract

Antiulcer and antioxidant activities of crude methanol (800 and 1600 mg/kg bw), n-hexane and ethyl acetate fractions (800 mg/kg bw) of Agelanthus dodoneifolius were investigated against acetylsalicylate and ethanol induced ulcer in rats. The methanol fraction had the highest ulcer protective effect (73.33 ± 7.40%), better than the cimetidine (60.00±8.54 %) while the ethyl acetate fraction had the least (26.66 ± 6.66 %) in ethanol model, however, in acetyl salicylate model, crude extract exhibited the highest (54.16 ± 4.16 %) and the lowest (33.33 ± 4.16 %) protective effect at 1600 and 800 mg/kgbw respectively. The methanol faction preserved the integrity of the epithelial mucosal better than the other fractions. Treatment with crude and fractions of A. dodenofolius significantly (p<0.05) increased the activities of SOD and Catalase and decreases the MDA concentration when compared with ulcerative untreated rats in both ulcer models. In conclusion, A. dodoneifolius could serve as a sources of new plant based antiulcer agent.