Please use this identifier to cite or link to this item:
http://ir.futminna.edu.ng:8080/jspui/handle/123456789/17612| Title: | Computational Model for Comparative Analysis of MRI Contrast Agents |
| Authors: | Dada, Michael Awojoyogbe, Bamidele Jayeoba, Babatunde |
| Keywords: | MRI contrast agents pharmacokinetic properties physiological environments NMR profiles |
| Issue Date: | 23-Jul-2016 |
| Publisher: | Springer Nature Switzerland |
| Citation: | Dada, O. M., Awojoyogbe, O. B. & Jayeoba, O. B. (2016). Computational Model for Comparative Analysis of MRI Contrast Agents. In the Proceedings of the World Molecular Imaging Congress (WMIC) September 2-5, 2015, Hawaii, United States [Molecular Imaging and Biology (2016) 18(Suppl 1): 1]. |
| Series/Report no.: | Curriculum Vitae;37 |
| Abstract: | The efficacy of MRI contrast agents (CAs) is not only determined by their pharmacokinetic properties but also by their magnetic properties as given by their T1 -and T2 -relaxivities [1,2]. It is very important to conduct comparative investigation on a large number of MRI CAs because their properties are dependent on different physiological environments (PEs) & binding to macromolecules in the blood [2]. Hence, different CAs are designed for different imaging objectives. However, the individual linearities of relaxation rates vs concentration is difficult to quantify using the experimental measurements in a wider concentration range due to the large amount of samples investigated at several magnetic field strengths and in different solvents [2]. Hence, we have developed a model and computer program for comparative analysis of NMR profiles of CAs in different PEs. |
| Description: | https://link.springer.com/article/10.1007/s11307-016-0969-2 |
| URI: | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/17612 |
| ISSN: | DOI: 10.1007/s11307-016-0969-2 |
| Appears in Collections: | Physics |
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