Effect of Sesamum indicum (Linn) Seeds Supplemented Diets on Blood Glucose, Lipid Profiles and Serum Levels of Enzymes in Alloxan Induced Diabetic Rats

Abstract

The present study was aimed at evaluating the effect of Sesamum indicum (linn) seeds supplemented diets on blood glucose, lipid profiles and serum enzymes in alloxan induced diabetic rats. Forty male albino Wistar rats were divided into two broad groups based on diet supplementation with raw and roasted Sesamum indicum. Each broad group consisted of five subgroups of four rats (normoglycemic control, diabetic control, standard drug-glibenclamide treated, diabetic rat treated with 10% Sesamum indicum supplemented diet and 20% Sesamum supplemented diet) for five weeks. Diabetes was induced by a single dose of freshly prepared alloxan (100 mg/kg b.wt) given intraperitonealy. Blood glucose level was monitored using glucometer. Serum lipid profile and serum enzymes were determined using standard spectrophotometric methods. There was a significant (p<0.05) reduction in the blood glucose levels of groups fed diets supplemented with raw and roasted sesame seed by about 34.89% and 37.33% respectively when compared to the diabetic control at the end of the experiment. The trend obtained for blood glucose levels was similar with that observed with the serum levels of cholesterol, triglycerides and low density lipoproteins at the same level of significance (p<0.05). The supplemented diets were able to increase the high density lipoprotein that was found to be low in the diabetic rats. The levels of serum enzymes found to be high in the diabetic rats were significantly (p<0.05) decreased at the end of the experiment with the supplemented diets. This study has shown that Sesamum indicum (Linn) seed either raw or roasted is capable of lowering the high blood glucose, lipid levels and some serum enzymes derangement observed in diabetes