Please use this identifier to cite or link to this item: http://ir.futminna.edu.ng:8080/jspui/handle/123456789/2012
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dc.contributor.authorAdefolalu, Fumilola S.-
dc.contributor.authorGara, Theresa Y.-
dc.contributor.authorAbubakar, Asmau N.-
dc.date.accessioned2021-06-07T22:17:30Z-
dc.date.available2021-06-07T22:17:30Z-
dc.date.issued2019-12-
dc.identifier.citationAdefolalu, F.S., Salawu, J.S., Gara, T.Y., and Abubakar, A.N. (2019). Hypoglycemic and Hypolipidemic Activity of the Oral Administration of Methanol Extract of Hibiscus Sabdariffa Seeds in Alloxan Induced Diabetic Albino Rats. Nigerian Journal of Basic and Applied Sciences, 27(2), 151-156.en_US
dc.identifier.issn0794-5698-
dc.identifier.urihttp://repository.futminna.edu.ng:8080/jspui/handle/123456789/2012-
dc.description.abstractextract of Hibiscus sabdariffa seed in alloxan induced diabetic albino rats. Two different doses (200 and 400 mg/kg) of the methanol extract of Hibiscus sabdariffa seed were administered daily to two groups of diabetic rats for a period of two weeks. Metformin (250 mg/kg) was given as the reference standard drug. Phytochemical, acute toxicity, fasting blood glucose, body weight, cholesterol, triglycerides and lipoproteins levels were determined using standard methods. Acute toxicity of methanol extract of Hibiscus sabdariffa seed was estimated to be greater than 5000 mg/kg body weight. There was an initial decrease in the body weight of the experimental animals after induction of diabetes which increased significantly (p<0.05) by the second week of treatment. The fasting blood glucose levels of the treated diabetic rats were significantly decreased at the second week of treatment with the group that received 400 mg/kg of extract recording the lowest fasting blood glucose level. The cholesterol, triglycerides and low density lipoproteins levels of the diabetic treated rats were significantly reduced while the high density lipoproteins level significantly increased. It can therefore be concluded that Hibiscus sabdariffa seed has the ability to lower blood sugar and maintain a stable lipid level.en_US
dc.description.sponsorshipNoneen_US
dc.language.isoenen_US
dc.publisherNigerian Journal of Basic and Applied Scienceen_US
dc.subjectHypoglycemicen_US
dc.subjecthypolipidemicen_US
dc.subjectAlloxanen_US
dc.subjectPhytochemicalen_US
dc.subjectHibiscus sabdariffaen_US
dc.titleHypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Ratsen_US
dc.typeArticleen_US
Appears in Collections:Biochemistry

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