Assessment of some Enzymes and Haematological Parameters in Malaria patients resident in Minna Nigeria.

Abstract

The serum activities of Glutamate Pyruvate Transaminase (SGPT), Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP), Lactate Dehydrogenase(LDH) and Glucose -6-Phosphate Dehydrogenase (G6PD) were assayed in ninety eight (98) malaria patients attending Minna, General Hospital. Sixty eight (68) healthy volunteers were randomly selected and screened for these enzymes. Packed cell volume (PCV) levels of the patients and healthy individuals were also determined. Results obtained showed SGPT (36.92 ±2.11 IU/L), SGOT (35.04±2.23 IU/L), ALP (45.71±1.79 IU/L) and LDH (398.80±2.11 IU/L) except G6PD (7.13±1.24 U/gHb) were significantly (p<0.05) elevated in malaria patients in comparison to the healthy volunteers. When males alone were compared, a similar trend to the general population was obtained in the patients except LDH (304.95±31.38 IU/L) and G6PD (4.99±1.06 U/gHb) which were not significantly (p>0.05) different from the activities in the controls. SGPT (35.66±3.03 IU/L) and G6PD (8.69±1.02 U/gHb) were also significantly (p<0.05) elevated in male malaria patients compared to their female counterparts. Male patients had consistently higher enzyme activities in comparison to female patients with most values within the specified normal ranges except LDH which was elevated in both sexes. Packed cell volume was generally higher in the control group compared to malaria patients and this was irrespective of gender.