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http://ir.futminna.edu.ng:8080/jspui/handle/123456789/2716| Title: | Anti-tubercular activities and molecular characterization of salivary extract of leech (Hirudo medicinalis) against Mycobacterium tuberculosis |
| Authors: | Ojo, O.P Babayi, H Olayemi, I.K Peter, O.O FADIPE, Labake Ajoke Baba E Izebe K |
| Keywords: | GC-MS, Mycobacterium tuberculosis , Leech Salivary Extract |
| Issue Date: | 6-Mar-2018 |
| Publisher: | Journal of Tuberculosis Research, 6, 1-9 |
| Citation: | Ojo, O. P., Babayi, H., Olayemi, I. K., O. O. Peter., L. A. FADIPE., Baba, E. & Izebe, K. (2018). Anti-tubercular activities and molecular characterization of salivary extract of leech (Hirudo medicinalis) against Mycobacterium tuberculosis. Journal of Tuberculosis Research, 6, 1-9 |
| Series/Report no.: | 6; |
| Abstract: | Leech salivary extract (LSE) was screened for the anti-tubercular activity against Mycobacterium tuberculosisusing microbroth dilution method. The bioactive components in LSE were determined using Shimadzu GC-MS QP2010 SE. The LSE exhibited bactericidal effects on M. tuberculosis at 50% (v/v). The result of the GC-MS analysis of LSE revealed seventeen (17) bioac-tive components. The major fatty acid components were oleic acid (33.9%) and palmitic acid also known as hexadecanoic acid (22.6%). Other bioactive components detected in appreciable amounts in LSE include, 4-bromobutyric acid (16.86%), 6,17-Octadiene-1-ol acetate (9.78%) and octahydro-1,4,9,9-tetramethyl (5.21%). The anti-tubercular activity of the LSE was attributed to these bioactive components.The results obtained suggest that leech salivary extract could be used in treating tuberculosis. |
| URI: | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/2716 |
| ISSN: | 2329-8448 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Anti-TbofLeech.pdf | 387.23 kB | Adobe PDF | View/Open |
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