Extraction, isolation and characterization of some alkaloids from the stem bark of Pericopsis laxiflora

Abstract

Extraction and purification of some of the nitrogenous bases present in the bark of Pericopsislaxifloraled to the isolation and characterization of three alkaloids. The structures of the isolated compounds on the basis of physical, chemical and spectral techniques, such as IR, UV, 1H-NMR, 13C-NMR, Dept-135 and GC-MS were elucidated as 5,8-Dimethyl-1,2,3,4-tetrahydro-9-acridinamine (1), 4,6-Diaminopyrazolo[3,4-d] pyrimidine (2) and 1,2,3,4,5,6- hexahydro-1,5-methano-8H-pyrido[1,2-a]diazocin-8-one (3).The presence of these nitrogenous bases, with many more yet to be isolated and characterized, is an indication that the plant may provide drugs that will help increase the therapeutic arsenal.